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Zoloft is well tolerated and effective for the treatment of depression and certain anxiety conditions. Zoloft is FDA approved to treat depression, certain types of social anxiety conditions, posttraumatic stress disorder (PTSD), panic disorder, obsessive-compulsive disorder (OCD), and premenstrual dysphoric disorder (PMDD) in adults over age 18. It is also approved for OCD in children and adolescents age 6-17 years.

Venlafaxine (Effexor, Efexor, Alventa, Argofan, Trevilor) is an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI). First introduced by Wyeth in 1993, it is licensed for the treatment of major depressive disorder (MDD), as an anxiolytic, and comorbid indications. In 2007, venlafaxine was the sixth most commonly prescribed antidepressant on the U.S. retail market, with 17.2 million prescriptions.

PAXIL is indicated for the treatment of major depressive disorder. The efficacy of PAXIL in the treatment of a major depressive episode was established in 6-week controlled trials of outpatients whose diagnoses corresponded most closely to the DSM-III category of major depressive disorder.

Bupropion belongs to the family of medications known as antidepressants. It is used to treat depression (Wellbutrin) and as an aid for quitting smoking (Zyban). It works by affecting the balance of chemicals that occur naturally in the brain.